The FoxA factors in organogenesis and differentiation
作者： Klaus H Kaestner
DOI: 10.1016/J.GDE.2010.06.005
关键词:
摘要: The genetic analysis of the Foxa genes in both total and conditional mutant mice has clearly established that organogenesis multiple systems is controlled by this subfamily winged helix transcription factors. These discoveries followed establishment conceptional framework mechanism action FoxA proteins as 'pioneer factors' can engage chromatin before other Recent molecular genomic studies have also shown facilitate binding several nuclear receptors to their respective targets a context-dependent manner, greatly increasing range importance factors biology.
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