Brain volumes predict neurodevelopment in adolescents after surgery for congenital heart disease

摘要: Patients with complex congenital heart disease are at risk for neurodevelopmental impairments. Evidence suggests that brain maturation can be delayed and pre- postoperative injury may occur, there is limited information on the long-term effect of development function in adolescent patients. At a mean age 13.8 years, 39 survivors childhood cardiopulmonary bypass surgery no structural lesions evident through conventional cerebral magnetic resonance imaging 32 healthy control subjects underwent extensive assessment imaging. Cerebral scans were analysed quantitatively using surface-based voxel-based morphometry. Compared subjects, patients had lower total (P = 0.003), white matter 0.004) cortical grey 0.005) volumes, whereas cerebrospinal fluid volumes not different. Regional volume reduction ranged from 5.3% (cortical matter) to 11% (corpus callosum). Adolescents cyanotic showed more loss than those acyanotic disease, particularly matter, thalami, hippocampi corpus callosum (all P-values < 0.05). Brain correlated significantly cognitive, motor executive functions (grey matter: P 0.05, 0.01). Our findings suggest long-lasting changes these associated functional outcome.