Preparation of estradiol chitosan nanoparticles for improving nasal absorption and brain targeting

作者: Xiaomei Wang , Na Chi , Xing Tang

DOI: 10.1016/J.EJPB.2008.07.005

关键词: Absorption (skin)MicroparticleNasal AbsorptionNasal administrationPharmacologyMicrodialysisChitosanCerebrospinal fluidChemistryPharmacokinetics

摘要: … , aiming at reducing nasal mucociliary clearance and enhancing permeation of E 2 into the nasal mucosa, and then improving the E 2 bioavailability, especially for brain targeting. …

参考文章(35)
Lisbeth Illum, Per Artursson, Tuulikki Lindmark, Stanley S. Davis, Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2). Pharmaceutical Research. ,vol. 11, pp. 1358- 1361 ,(1994) , 10.1023/A:1018967116988
Henrik. L. Lueßen, Bas. J. de Leeuw, Mariska W. E. Langemeÿer, A.(Bert) G. de Boer, J. Coos. Verhoef, Hans E. Junginger, Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo. Pharmaceutical Research. ,vol. 13, pp. 1668- 1672 ,(1996) , 10.1023/A:1016488623022
Lisbeth Illum, Nidal F. Farraj, Stanley S. Davis, Chitosan as a Novel Nasal Delivery System for Peptide Drugs Pharmaceutical Research. ,vol. 11, pp. 1186- 1189 ,(1994) , 10.1023/A:1018901302450
Erik Björk, Peter Edman, Characterization of degradable starch microspheres as a nasal delivery system for drugs International Journal of Pharmaceutics. ,vol. 62, pp. 187- 192 ,(1990) , 10.1016/0378-5173(90)90232-S
H. CRITCHLEY, S. S. DAVIS, N. F. FARRAJ, L. ILLUM, Nasal absorption of desmopressin in rats and sheep. Effect of a bioadhesive microsphere delivery system. Journal of Pharmacy and Pharmacology. ,vol. 46, pp. 651- 656 ,(2011) , 10.1111/J.2042-7158.1994.TB03876.X
Hirai Shinichiro, Yashiki Takatsuka, Matsuzawa Tai, Mima Hiroyuki, Absorption of drugs from the nasal mucosa of rat International Journal of Pharmaceutics. ,vol. 7, pp. 317- 325 ,(1981) , 10.1016/0378-5173(81)90058-2
Alexander H. Krauland, Davide Guggi, Andreas Bernkop-Schnürch, Thiolated chitosan microparticles: a vehicle for nasal peptide drug delivery. International Journal of Pharmaceutics. ,vol. 307, pp. 270- 277 ,(2006) , 10.1016/J.IJPHARM.2005.10.016
H. Kölsch, M. L. Rao, Neuroprotective effects of estradiol-17beta: implications for psychiatric disorders. Archives of Womens Mental Health. ,vol. 5, pp. 105- 110 ,(2002) , 10.1007/S00737-002-0005-1
Ulrika Westin, Elena Piras, Björn Jansson, Ulrika Bergström, Maria Dahlin, Eva Brittebo, Erik Björk, Transfer of morphine along the olfactory pathway to the central nervous system after nasal administration to rodents European Journal of Pharmaceutical Sciences. ,vol. 24, pp. 565- 573 ,(2005) , 10.1016/J.EJPS.2005.01.009
L. Ilium, N. Farraj, H. Critchley, S.S. Davis, Nasal administration of gentamicin using a novel microsphere delivery system International Journal of Pharmaceutics. ,vol. 46, pp. 261- 265 ,(1988) , 10.1016/0378-5173(88)90087-7