Modeling neurodegenerative disorders in adult somatic cells: A critical review
作者： An Truong , Emily Si , Thomas Duncan , Michael Valenzuela
DOI: 10.1007/S11515-016-1413-3
关键词: Neuroscience 、 Disease 、 Somatic cell 、 Reprogramming 、 Phenotype 、 Neurodegeneration 、 Proteomics 、 Biology 、 Stem cell 、 Amyotrophic lateral sclerosis
摘要: Development of new therapeutic targets for neurodegenerative disorders has been hampered by a reliance on post mortem tissue that is representative end-stage disease, or animal models fail to provide faithful analogs. However, rapid advances in cellular genetic reprogramming, particular the induction somatic cells into stem cells, directly neurons, led intense interest modeling human neurodegeneration vitro. Here, we critically review current methods and recent progress Alzheimer’s Parkinson’s disease amyotrophic lateral sclerosis. Several challenges are identified, including technical variability, lack degenerative phenotypes, neurodevelopmental age establishing ground truths sporadic disease. Recommendations evaluating proposed along with suggestions future research.
springer.com
sci-hub.se 参考文章(88)
Fiona Thomson, Parkinson's Disease Neuron. ,vol. 39, pp. 889- 909 ,(2003) , 10.1016/S0896-6273(03)00568-3
Nigel J. Cairns, Richard J. Perrin, Erin E. Franklin, Deborah Carter, Benjamin Vincent, Mingqiang Xie, Randall J. Bateman, Tammie Benzinger, Karl Friedrichsen, William S. Brooks, Glenda M. Halliday, Catriona McLean, Bernardino Ghetti, John C. Morris, , , Neuropathologic assessment of participants in two multi-center longitudinal observational studies: the Alzheimer Disease Neuroimaging Initiative (ADNI) and the Dominantly Inherited Alzheimer Network (DIAN). Neuropathology. ,vol. 35, pp. 390- 400 ,(2015) , 10.1111/NEUP.12205
H. Braak, E. Braak, Evolution of neuronal changes in the course of Alzheimer’s disease Journal of Neural Transmission. Supplementa. ,vol. 53, pp. 127- 140 ,(1998) , 10.1007/978-3-7091-6467-9_11
Grant Coan, Cassie S. Mitchell, An Assessment of Possible Neuropathology and Clinical Relationships in 46 Sporadic Amyotrophic Lateral Sclerosis Patient Autopsies Neurodegenerative Diseases. ,vol. 15, pp. 301- 312 ,(2015) , 10.1159/000433581
Daniel J. Schaid, Stephen N. Thibodeau, Robert J. Ivnik, Eric G. Tangalos, Glenn E. Smith, Emre Kokmen, Ronald C. Petersen, M. S. Tsai, Apolipoprotein E: risk factor for Alzheimer disease. American Journal of Human Genetics. ,vol. 54, pp. 643- 649 ,(1994)
John C.S. Breitner, Comment: Yet another "disconnect" between amyloid and Alzheimer disease? Neurology. ,vol. 85, pp. 698- 698 ,(2015) , 10.1212/WNL.0000000000001871
Jerome Mertens, Apuã CM Paquola, Manching Ku, Emily Hatch, Lena Böhnke, Shauheen Ladjevardi, Sean McGrath, Benjamin Campbell, Hyungjun Lee, Joseph R Herdy, J Tiago Gonçalves, Tomohisa Toda, Yongsung Kim, Jürgen Winkler, Jun Yao, Martin W Hetzer, Fred H Gage, None, Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects Cell Stem Cell. ,vol. 17, pp. 705- 718 ,(2015) , 10.1016/J.STEM.2015.09.001
Etsuro Ohta, Tomoko Nihira, Akiko Uchino, Yoichi Imaizumi, Yohei Okada, Wado Akamatsu, Kayoko Takahashi, Hideki Hayakawa, Makiko Nagai, Manabu Ohyama, Masafuchi Ryo, Mieko Ogino, Shigeo Murayama, Akihiko Takashima, Kazutoshi Nishiyama, Yoshikuni Mizuno, Hideki Mochizuki, Fumiya Obata, Hideyuki Okano, I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway Human Molecular Genetics. ,vol. 24, pp. 4879- 4900 ,(2015) , 10.1093/HMG/DDV212
Young Hye Kim, Se Hoon Choi, Carla D'Avanzo, Matthias Hebisch, Christopher Sliwinski, Enjana Bylykbashi, Kevin J Washicosky, Justin B Klee, Oliver Brüstle, Rudolph E Tanzi, Doo Yeon Kim, A 3D human neural cell culture system for modeling Alzheimer's disease Nature Protocols. ,vol. 10, pp. 985- 1006 ,(2015) , 10.1038/NPROT.2015.065
Rubén Fernández‐Santiago, Iria Carballo‐Carbajal, Giancarlo Castellano, Roger Torrent, Yvonne Richaud, Adriana Sánchez‐Danés, Roser Vilarrasa‐Blasi, Alex Sánchez‐Pla, José Luis Mosquera, Jordi Soriano, José López‐Barneo, Josep M Canals, Jordi Alberch, Ángel Raya, Miquel Vila, Antonella Consiglio, José I Martín‐Subero, Mario Ezquerra, Eduardo Tolosa, Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients Embo Molecular Medicine. ,vol. 7, pp. 1529- 1546 ,(2015) , 10.15252/EMMM.201505439