Neuropathologic assessment of participants in two multi-center longitudinal observational studies: the Alzheimer Disease Neuroimaging Initiative (ADNI) and the Dominantly Inherited Alzheimer Network (DIAN).

摘要: It has been hypothesized that the relatively rare autosomal dominant Alzheimer disease (ADAD) may be a useful model of more frequent, sporadic, late-onset AD (LOAD). Individuals with ADAD have predictable age at onset and biomarker profile participants in preclinical stage used to predict progression clinical onset. However, extent which pathogenesis neuropathology overlaps LOAD is equivocal. To address this uncertainty, two multicenter longitudinal observational studies, Disease Neuroimaging Initiative (ADNI) Dominantly Inherited Network (DIAN), leveraged expertise resources existing Knight Research Center (ADRC) Washington University School Medicine, St. Louis, Missouri, USA, establish Neuropathology Core (NPC). The ADNI/DIAN-NPC systematically examining brains all who come autopsy 59 ADNI sites USA Canada 14 DIAN (eight), Australia (three), UK (one) Germany (two). By 2014, 41 24 autopsies (involving nine 15 family members) had performed. rate cohort most recent year was 93% (total since NPC inception: 70%). In summary, ADNI/DIAN implemented standard protocol for solicit permission brain send tissue standardized, uniform state-of-the-art neuropathologic assessment. benefit implementation very clear. provides final "gold standard" neuropathological diagnoses data against antecedent observations measurements can compared.