Multiple effects of acetaminophen and p38 inhibitors: Towards pathway toxicology
作者： Jinghai J. Xu , Bart S. Hendriks , Jie Zhao , David de Graaf
DOI: 10.1016/J.FEBSLET.2008.01.063
关键词: MAPK/ERK pathway 、 Toxicology 、 ACETAMINOPHEN TOXICITY 、 Biological pathway 、 Molecular interactions 、 Systems biology 、 Biology
摘要: The majority of drug-related toxicities are idiosyncratic, with little pathophysiological insight and mechanistic understanding. Pathway toxicology is an emerging field in the post-genomic era that studies molecular interactions between toxicants biological pathways as a way to bridge this knowledge gap. Using two case – acetaminophen p38 MAPK inhibitors review illustrates how pathway-based perspective has advanced our understanding compound target-based toxicities. advancement pathway will be dependent on integrated applications techniques from basic sciences fundamental interdependence multiple living organisms.
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