Preventive effect of apigenin against isoproterenol-induced apoptosis in cardiomyoblasts.
作者： Radhiga Thangaiyan , Beaulah Mary Robert , Sundaresan Arjunan , Kanimozhi Govindasamy , Rajendra Prasad Nagarajan
DOI: 10.1002/JBT.22213
关键词: DNA damage 、 Pharmacology 、 Cytochrome 、 Apigenin 、 Oxidative dna damage 、 Apoptosis 、 Chemistry 、 Isoproterenol Hydrochloride
摘要: We investigated the effect of apigenin, a dietary flavonoid, on isoproterenol hydrochloride (ISO)-induced apoptotic signaling in cardiomyoblast H9C2 cells. The results showed that apigenin treatment (10 µM) prevented ISO (31.25 μM)-induced lipid peroxidative levels and antioxidants status Furthermore, inhibited expression inflammatory markers ISO-treated In addition, ISO-induced DNA damage through modulating Bax, caspase-3, -8 -9, cytochrome c, Fas proteins It is concluded prevents depletion, oxidative damage, inflammatory, Thus, present demonstrated has cardioprotective cardiomyoblasts
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