IL-6 levels in acute and post myocardial infarction: their relation to CRP levels, infarction size, left ventricular systolic function, and heart failure

摘要: BACKGROUND: Inflammatory mechanisms in heart disease are of great interest. The proinflammatory cytokine interleukin (IL) 6 has been linked to increased morbidity unstable angina pectoris and depressed myocardial function failure (HF). METHODS: We studied the relation IL-6 levels C-reactive protein (CRP), infarction size, left ventricular function, HF acute (MI) after hospital discharge 31 consecutive patients (19 males, mean age 69+/-13 years). Blood sampling for was performed on admittance, four times day 1, twice 2, once daily days 3-5, 12 weeks later. Clinical signs were evaluated during hospitalization weeks. Echocardiography 3 at RESULTS: showed a curved time course with elevated already admittance (mean+/-S.D. 19.3+/-26.9 ng/l), thereafter increasing peak 1 2 (maximum 68.5+/-152.9 then declining rapidly lower, although not normalized, CRP similar pattern, but later seemingly less rapid decline levels. Mean 1-5 correlated highly (r=0.794, p<0.0001). size did correlate. related IL-6; however, had higher levels, both Patients ACE inhibitors or diuretics LVF; yet, LVF CONCLUSIONS: MI shows is CRP. It peaks remains even Increased associated LVF. Whether anti-inflammatory agents will influence dysfunction outcome postacute yet be determined.