Fate of neuron–glia synapses during proliferation and differentiation of NG2 cells

摘要: Progenitor cells expressing proteoglycan NG2 (also known as oligodendrocyte precursor or polydendrocytes) are widespread in the grey and white matter of CNS; they comprise 8-9% total cell population adult matter, 2-3% matter. have a complex stellate morphology, with highly branched processes that may extend more than 100 μm around body. express set voltage-gated channels, AMPA/kainate and/or γ-aminobutyric acid (GABA)(A) receptors, receive glutamatergic GABAergic synaptic input from neurons. In every region brain found proliferative cells, fraction actively cycling is quite high young well animals. During development either differentiate into myelinating oligodendrocytes (and possibly also few astrocytes neurons) persist parenchyma cells. This review highlights new findings related to morphological electrophysiological changes fate between neurons during proliferation differentiation these neonatal nervous system rodents.