Protease-activated receptors

摘要: Certain serine proteases from the circulation (e.g., coagulation factors), inflammatory cells mast-cell tryptase, neutrophil proteinase 3), and many other cell types trypsins) can specifically signal to by cleaving protease-activated receptors (PARs), a family of four G protein-coupled receptors. Proteases cleave PARs at specific sites within extracellular amino-terminus expose amino-terminal tethered ligand domains that bind activate cleaved The are often generated released during injury inflammation, activated orchestrate tissue responses injury, including hemostasis, pain, repair. This review concerns protease PAR signaling in nervous system. Neurons central peripheral systems express all PARs. may derive circulation, cells, or neural tissues on neurons thereby diverse pathways control survival, morphology, release neurotransmitters, activity ion channels. In this manner regulate neurodegeneration, neurogenic pain transmission. Thus, participate disease states antagonists agonists be useful therapies for certain disorders.