Neural correlates of emotional response inhibition in obsessive-compulsive disorder: A preliminary study
作者： Heather A. Berlin , Kurt P. Schulz , Sam Zhang , Rachel Turetzky , David Rosenthal
DOI: 10.1016/J.PSCYCHRESNS.2015.09.019
关键词: Developmental psychology 、 Neural correlates of consciousness 、 Neuroimaging 、 Psychology 、 Amygdala 、 Cerebral cortex 、 Neuroscience 、 Response inhibition 、 Disgust 、 Insula 、 Cortex (botany)
摘要: Failure to inhibit recurrent anxiety-provoking thoughts is a central symptom of obsessive-compulsive disorder (OCD). Neuroimaging studies suggest inhibitory control and disgust processing abnormalities in patients with OCD. However, the emotional modulation response inhibition deficits OCD their neural correlates remain be elucidated. For this preliminary study we administered an adapted affective paradigm, go/no-go task, during fMRI characterize systems underlying disgust-related fear-related nine adults contamination-type compared ten matched healthy controls. Participants had significantly greater anterior insula cortex activation when inhibiting responses both disgusting (bilateral), fearful (right-sided) images, They also increased several frontal, temporal, parietal regions, but there was no evidence amygdala or participants significant between-group differences performance on emotion task. The appears play role images. may serve as potential treatment target for
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