γ-Aminobutyric acid-ergic analgesia: Implications for γ-aminobutyric acid-ergic therapy for drug addictions
作者： F.V. DeFeudis
DOI: 10.1016/0376-8716(84)90035-8
关键词: Drug tolerance 、 Aminooxyacetic acid 、 Baclofen 、 gamma-Aminobutyric acid 、 Endogenous opioid 、 Aminobutyric acid 、 Medicine 、 GABA receptor antagonist 、 Pharmacology 、 Anesthesia 、 Opioid peptide
摘要: Recent in vivo and vitro studies regarding the involvement of gamma-aminobutyric acid (GABA)-ergic systems analgesia opiate dependence have been reviewed analyzed. It seems evident that GABA-ergic play a role mediating effects opiates some interplay might exist between endogenous opioid systems. Systemic administration GABA-agonists, GABA uptake blockers inhibitors GABA-alpha-oxoglutarate transaminase (GABA-T) can produce potent analgesic actions experimental animals man. Further study such agents lead to development new analgesics and/or drugs for treating certain types drug addiction.
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