Pregabalin role in inhibition of morphine analgesic tolerance and physical dependency in rats.

摘要: Pregabalin is recently proposed as analgesic or adjuvant in pain management. While previous preclinical investigations have evaluated pregabalin-opioid interactions, the effect of pregabalin on opioid tolerance and dependency has not yet been studied. Here we effects different doses (50, 100 200mg/kg, s.c.) morphine-induced rats. Adult male Wistar rats were rendered tolerant to morphine by injection (10mg/kg, twice daily for 7 days. To develop dependence, given escalating morphine. determine development administrated before The tail-flick naloxone precipitation withdrawal tests used evaluate degree respectively. Chronic morphine-injected showed significant decrements percentage maximum possible (%MPE) days 5 (32.5%±3.5, 21.5%±4, respectively) compared first day (100%) which tolerance. 200mg/kg completely prevented In addition, concomitant treatment with attenuated almost all naloxone-induced signs include weight loss, jumping, penis licking, teeth chattering, wet dog shakes, rearing, standing, sniffing, face grooming paw tremor. These data show that pregabaline a potential anti-tolerant/anti-dependence property against chronic usage Therefore, appears be promising candidate addiction after confirming future clinical studies.