Pregabalin for the Treatment of Drug and Alcohol Withdrawal Symptoms: A Comprehensive Review.

摘要: Treatments for physical dependence and associated withdrawal symptoms following the abrupt discontinuation of prescription drugs (such as opioids benzodiazepines), nicotine, alcohol, cannabinoids are available, but there is still a need new more effective therapies. This review examines evidence supporting potential use pregabalin, an α2δ voltage-gated calcium channel subunit ligand, treatment symptoms. A literature search MEDLINE Cochrane Library databases up to including 11 December 2015 was conducted. The term used ‘(dependence OR withdrawal) AND pregabalin’. No other date limits were set no language restrictions applied. Works cited in identified articles cross-referenced personal archives references also searched. Articles included based on expert opinions authors. There limited role pregabalin accompanying with opioids, benzodiazepines, cannabinoids, although data from randomized controlled studies sparse. However, current promising provides platform future studies, appropriate randomized, placebo- and/or comparator-controlled further explore efficacy safety Given misuse or abuse, particularly individuals previous history substance clinicians should exercise caution when using this patient population.