A randomized single blind study of the efficacy of pregabalin in the treatment of opioid withdrawal syndrome

摘要: AIM To study the efficacy and safety of pregabalin (lyrica) in complex treatment opioid withdrawal syndrome (OWS). MATERIAL AND METHODS STUDY DESIGN single-blind randomized symptom-triggered protocol with an active control. Thirty-four patients were randomly assigned to two groups. The first group (n=19) received up 600 mg a day for six days along symptomatic therapy (basic symptom-triggered). second (n=15) micrograms clonidine as main same basic regimen. Opiate severity, craving, sleep disturbance, anxiety depression, well general clinical impressions side-effects assessed daily using internationally validated quantitative psychometric instruments. RESULTS In group, 15 out 19 (79%) completed compared 7 (47%) (p=0.05; Fisher exact test). There no statistically significant differences between groups on any assessments severity OWS (reduction opiate withdrawal), perhaps because small sample size. there lower indicators craving opiates (p=0.05), (p=0.05) depression (p<0.05), while patient-rated self-assessment their health condition was significantly better (p<0.05). frequency adverse events groups, though tolerability noted group. CONCLUSION Treatment regimen is effective safe tolerate it that leads higher detoxification completion rate (retention).