Investigation of a common physiological mechanism underlying progesterone-induced and maternal nesting in mice, Mus musculus.

作者: Carol B. Lynch , Jill E. Schneider

DOI: 10.1037//0735-7036.98.2.165

关键词: NestPlasma progesteroneSet pointInbred strainRadioimmunoassayEndocrinologyNesting (computing)ZoologyBiologyPregnancyMechanism (biology)Internal medicine

摘要: These experiments addressed the possibility that genetic differences in plasma progesterone levels underlie observed maternal nesting (nest building by pregnant mice). Because this hypothesis requires different circulating of result a corresponding elevation nesting, groups outbred females were treated with varying doses progesterone, and their was measured. The relation between dose not linear; rather, there appeared to be threshold above which all responded similarly. Next, four inbred strains lines selectively bred for nonpregnant (thermoregulatory) measured directly radioimmunoassay. rank order strains' selected lines' did correspond nesting. Thus, genetically based are due levels. Other results presented suggest thermo-regulatory mechanism underlying progesterone-mediated may involve thermal set point.

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