Interacting effects of oxazepam in late pregnancy and fostering procedure on mouse maternal behavior.
作者： Giovanni Laviola , Giorgio Bignami , Enrico Alleva
DOI: 10.1016/S0149-7634(05)80139-3
关键词:
摘要: The present study was designed to assess the proactive effects of late pregnancy benzodiazepine (BDZ) treatment on maternal behavior in postpartum period, using cross-fostering procedures control for role changes produced prenatally offspring. Outbred CD-1 mouse dams were treated with either oxazepam (OX, 15 mg/kg PO twice/day days 12–16) or vehicle (VEH). After parturition, entire litters exchanged within treatments (in-fostered groups, IF) between (cross-fostered CF), while additional left undisturbed (un-fostered UF). lactating observed their home cages at 4, 8, and 12 postpartum. Maternal responses, particularly nursing, reduced OX-UF OX-CF conditions normal enhanced OX-IF condition. Correspondingly, locomotor/exploratory activity markedly former close level latter In sum, fostering variable appeared determine whether pups raised by previously BDZ receive insufficient exaggerated care. This points need a better understanding mother/pup interactions studies aimed characterizing drug toxicant offspring development.
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