Quality of rearing guides expression of behavioral and neural seizure phenotypes in EL mice.

摘要: Abstract The present studies employed behavioral and neural markers of seizure-related plasticity to examine the relative contributions genetic predisposition versus rearing environment in generating adult phenotypes EL mice, a stress-induced animal model epilepsy. Early was manipulated by cross-fostering pups strain seizure-resistant CD-1 control mouse. impact changes quality on growth, exploratory stress-reactivity were examined, with focus role maternal care shaping seizure susceptibility cFos activation. Improvement imposed replacing biological dams foster mothers sufficient decrease pup mortality, increase body weight gain (+ 0.1 g/day) delay onset offspring beyond post-natal day 80–90. Moreover, hypoactivity hippocampus cortex among cross-fostered EL, but not control, suggests that accompanied enduring brain plasticity. Thus, mice are dependent upon post-partum which if systematically enhanced can postpone expression.