Malabsorption, villous atrophy, and excessive serum IgA in a patient with unusual intestinal immunocyte infiltration.

摘要: An 11-year-old boy with gastrointestinal complaints of about 4 years' duration was admitted to hospital in 1967 severe malabsorption and villous atrophy the small intestinal mucosa. The clinical symptoms disappeared association gluten withdrawal. During subsequent 10 years, however, has persisted, tests have been virtually unchanged. Moreover, his serum level IgA remained extremely high (58-66 g/l), along normal IgM IgG. His is mainly polymeric shows polyclonal characteristics. Immunohistochemical investigations demonstrated that mucosa its major production site. About 96 per cent immunocytes are class. increased number IgA-producing cells also present gastric mucosa, whereas nasal bone marrow show no abnormality, peripheral blood contains a IgA-bearing lymphocytes. permeates dermal mucosal connective ...