Quantitative Study of the Uptake of IgA by Isolated Rat Hepatocytes
作者： H. TOLLESHAUG , P. BRANDTZAEG , K. HOLTE
DOI: 10.1111/J.1365-3083.1981.TB00110.X
关键词: Biochemistry 、 Hepatocyte 、 Immunoglobulin A 、 Endocytic vesicle 、 Catabolism 、 Internalization 、 Endocytosis 、 Receptor 、 Secretory component 、 Biology
摘要: Recently dispersed rat hepatocytes showed high capacity for uptake of monomeric and polymeric human IgA by simple absorptive endocytosis. Maximum exceeded 15 million monomer units per cell. The asialo-glycoprotein receptor was not involved in this process. J chain-containing polymers were on the average taken up somewhat better than monomers substantially chain-deficient polymers. This result would agree with a partial involvement secretory component (SC) IgA. Different mechanism might hence explain hepatic transport from blood to bile perhaps be catabolism After binding plasma membrane hepatocyte, most internalized endocytic vesicles. A considerable proportion radiolabelled apparently reached lysosomes after internalization became degraded.
sci-hub.se 参考文章(33)
P Brandtzaeg, Human secretory immunoglobulin M. An immunochemical and immunohistochemical study. Immunology. ,vol. 29, pp. 559- 570 ,(1975)
J.C. Paulson, R.L. Hill, T. Tanabe, G. Ashwell, Reactivation of asialo-rabbit liver binding protein by resialylation with beta-D-galactoside alpha2 leads to 6 sialyltransferase. Journal of Biological Chemistry. ,vol. 252, pp. 8624- 8628 ,(1977) , 10.1016/S0021-9258(19)75266-1
WILLIAM L. FRANTZ, ROGER W. TURKINGTON, Formation of Biologically Active 125I-Prolactin by Enzymatic Radioiodination Endocrinology. ,vol. 91, pp. 1545- 1548 ,(1972) , 10.1210/ENDO-91-6-1545
H. Tolleshaug, T. Berg, Chloroquine reduces the number of asialo-glycoprotein receptors in the hepatocyte plasma membrane. Biochemical Pharmacology. ,vol. 28, pp. 2919- 2922 ,(1979) , 10.1016/0006-2952(79)90586-0
Kare Baklien, Olav Fausa, Per Brandtzaeg, Stig S. Fröland, Egil Gjone, Malabsorption, villous atrophy, and excessive serum IgA in a patient with unusual intestinal immunocyte infiltration. Scandinavian Journal of Gastroenterology. ,vol. 12, pp. 421- 432 ,(1977) , 10.3109/00365527709181683
W. Huisman, Lineke Lanting, H.J. Doddema, J.M.W. Bouma, M. Gruber, ROLE OF INDIVIDUAL CATHEPSINS IN LYSOSOMAL PROTEIN DIGESTION AS TESTED BY SPECIFIC INHIBITORS Biochimica et Biophysica Acta. ,vol. 370, pp. 297- 307 ,(1974) , 10.1016/0005-2744(74)90054-0
E Orlans, J Peppard, J Reynolds, J Hall, Rapid active transport of immunoglobulin A from blood to bile. Journal of Experimental Medicine. ,vol. 147, pp. 588- 592 ,(1978) , 10.1084/JEM.147.2.588
D.J. Socken, B.J. Underdown, Comparison of human, bovine and rabbit secretory component-immunoglobulin interactions Immunochemistry. ,vol. 15, pp. 499- 506 ,(1978) , 10.1016/0161-5890(78)90080-9
H. Tolleshaug, T. Berg, W. Frölich, K.R. Norum, Intracellular localization and degradation of asialofetuin in isolated rat hepatocytes Biochimica et Biophysica Acta (BBA) - General Subjects. ,vol. 585, pp. 71- 84 ,(1979) , 10.1016/0304-4165(79)90326-X
P. BRANDTZAEG, Complex formation between secretory component and human immunoglobulins related to their content of J chain. Scandinavian Journal of Immunology. ,vol. 5, pp. 411- 419 ,(1976) , 10.1111/J.1365-3083.1976.TB00295.X