Effects of bilirubin ditaurate on biliary secretion of proteins and lipids : influence on the hepatic vesicle transport system
作者： Tsuyoshi Kajihara , Susumu Tazuma , Gunji Yamashita , Goro Kajiyama
DOI: 10.1046/J.1440-1746.1999.01917.X
关键词:
摘要: Background: Several organic anions cause dissociation of biliary lipid secretion from bile acid (uncoupling). As lipids originate liver microsomes and are transported by carrier proteins and/or transcytotic vesicles, such a reduction may lead to cytosolic accumulation vesicles. This study investigated whether bilirubin conjugate, physiologically important anion, caused uncoupling hepatic retention compounds carried vesicles occurred subsequently, using ditaurate, synthetic commercially available compound. Methods: Cannulation the duct femoral vein was done in male Sprague-Dawley rats. Sodium taurocholate infused intravenously at constant rate 100 nmol/min per g bodyweight. Bilirubin ditaurate (50 bodyweight) concomitantly, followed periodical collection for analysis lipids, total protein immunoglobulin A. Results: Biliary not changed significantly infusion ditaurate. In contrast, cholesterol, phospholipids A decreased 57.3, 48.7 44.8%, respectively. The cholesterol:phospholipid ratio increased 19%. Uncoupling decreased. Conclusions: is major intrahepatic involve impairment vesicular transport. Also, into anion-induced weaken immunity. © 1999 Blackwell Science Asia Pty Ltd
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