Clinical metabolomics paves the way towards future healthcare strategies.
作者： Sebastiano Collino , François-Pierre J. Martin , Serge Rezzi
DOI: 10.1111/J.1365-2125.2012.04216.X
关键词: Computational biology 、 Disease 、 Metabolic regulation 、 Gut microflora 、 Metabolomics 、 Health care 、 Bioinformatics 、 Population 、 Biology
摘要: Metabolomics is recognized as a powerful top-down system biological approach to understand genetic-environment-health paradigms paving new avenues identify clinically relevant biomarkers. It nowadays commonly used in clinical applications shedding light on physiological regulatory processes of complex mammalian systems with regard disease aetiology, diagnostic stratification and, potentially, mechanism action therapeutic solutions. A key feature metabolomics lies its ability underpin the metabolic interactions host commensal microbial partners providing way define individual and population phenotypes. This review aims at describing recent fields insight into diseases, diagnostics/monitoring improvement homeostatic regulation.
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