Venusol from Gunnera perpensa: structural and activity studies.
作者： Fatima Khan , Xolani K Peter , Rod M Mackenzie , Lynn Katsoulis , Ronette Gehring
DOI: 10.1016/J.PHYTOCHEM.2004.02.024
关键词: Pyrogallol 、 Biochemistry 、 Phenylpropanoid 、 Ellagic acid 、 Succinic acid 、 Contractility 、 Glucoside 、 Chemistry 、 Lactic acid 、 Rhizome
摘要: From the aqueous extract of dry rhizomes Gunnera perpensa minor components pyrogallol, succinic acid, lactic and trimethyl ether ellagic acid glucoside were isolated. The major constituent was identified as Z-venusol, a phenylpropanoid glucoside. Its structure verified by X-ray diffraction. Tests on isolated uterine smooth muscle from rats showed that whole stimulated direct contractile response induced state continuous contractility uterus once all additives had been removed organ bath. By contrast, venusol did not trigger but bath flushed.
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