Labor induction and meconium: in vitro effects of oxytocin, dinoprostone and misoprostol on rat ileum relative to myometrium.

摘要: Background. Oxytocin and various prostaglandin preparations are commonly used for pharmacological induction of labor at term. Some appear to be associated with more fetal meconium passage maternal gastrointestinal side effects than is oxytocin. These adverse may caused by stimulation bowel smooth muscle in the mother fetus. Aim. To determine whether vitro ileal contractile activities dinoprostone, misoprostol oxytocin keeping variation rates staining observed during these substances. Methods. The activity drugs was tested on isolated rat uterus ileum mounted inTyrode's solution. Results. Uterine contractions were stimulated all three drugs, whereas only dinoprostone misoprostol. had no ileum. Dinoprostone significantly (p < 0.05) larger uterine contractions. Conclusion. results provide a basis increased rate complaints using compared Based above findings, we postulate that difference following administration pharmacokinetic rather pharmacodynamic differences between two drugs.