Interactions of oral β-carotene and canthaxanthin in ferrets

摘要: Interactive effects of an oral dose equal quantities beta-carotene and either canthaxanthin or lycopene on serum tissue accumulations were investigated in domestic ferrets. Like humans, ferrets absorb a substantial portion ingested intact accumulate it tissues. After the low carotenoid purified diet for 13 d, they randomly assigned to one two groups six animals. One group was dosed with (10 mg/kg body weight) other (Experiment 1) 2) weight each). In Experiment 1, that received combined had concentrations significantly lower at 8, 12 24 h post-dosing (P < 0.05), compared those individual beta-carotene; liver, adrenal kidney also reduced. 2, than alone; differences not statistically significant exception post-dosing. The results suggest that, doses given, concurrent has specific antagonistic effect bioavailability