Cardiac renewing: interstitial Cajal-like cells nurse cardiomyocyte progenitors in epicardial stem cell niches.

摘要: Recent studies suggested that various cell lineages exist within the subepicardium and we supposed this area could host cardiac stem niches (CSCNs). Using transmission electron microscopy, have found at least 10 types of cells coexisting in normal adult mice: adipocytes, fibroblasts, Schwann nerve fibres, isolated smooth muscle cells, mast macrophages, lymphocytes, interstitial Cajal-like (ICLCs) cardiomyocytes progenitors (CMPs). The latter sited origin coronary arteries aorta, showed typical features either very immature or developing cardiomyocytes. Some these were connected to each other form columns surrounded by a basal lamina embedded cellular network made ICLCs. Complex intercellular communication occurs between ICLCs CMPs through electron-dense nanostructures shed vesicles. We provide here for first time ultrastructural description CSCN mice myocardium, mainly containing CMPs. existence resident different developmental stages proves renewing is continuous process. suggest might act as supporting nurse may be responsible activation, commitment migration out niches. Briefly, not only but also regulate myocyte turnover contribute both homeostasis endogenous repair/remodelling after injuries.