Prostate cancer cells differ in testosterone accumulation, dihydrotestosterone conversion, and androgen receptor signaling response to steroid 5α‐reductase inhibitors

作者: Yue Wu , Alejandro Godoy , Faris Azzouni , John H. Wilton , Clement Ip

DOI: 10.1002/PROS.22694

关键词: Androgen receptorDutasterideMedicineProstate cancerTestosteroneDihydrotestosterone5 Alpha-Reductase InhibitorFinasterideInternal medicineEndocrinologyAndrogen

摘要: BACKGROUND Blocking 5α‐reductase‐mediated testosterone conversion to dihydrotestosterone (DHT) with finasteride or dutasteride is the driving hypothesis behind two prostate …

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