Bilateral inhibition generates neuronal responses tuned to interaural level differences in the auditory brainstem of the barn owl

摘要: I investigated the neural algorithms by which neurons gain selectivity for interaural level difference in brainstem of barn owl (Tyto alba). Differences timing and sounds at ears are used this to encode, respectively, azimuthal vertical position sound sources space. These two cues processed parallel pathways. Below inferior colliculus, all pathway that processes differences show responses cue monotonic, thus not selective a particular difference. Only contains map auditory space, sharply tuned specific differences. How these response properties generated from those nuclei provide input colliculus? posterior subdivision nucleus ventralis lemnisci lateralis (VLVp) projects bilaterally lateral shell central stage Both part Manipulations VLVp affected colliculus; time were unaffected. By systematically increasing or decreasing activity VLVp, on each side provides inhibition colliculus large This results peaked is colliculus. Some cells appear receive direct GABAergic VLVp. suggest circuitry it supports substrates allow exploit computation source elevation.