Solution structure of the extended neuronal nitric oxide synthase PDZ domain complexed with an associated peptide
作者： Mingjie Zhang , Hidehito Tochio , Qiang Zhang , Pravat Mandal , Ming Li
DOI: 10.1038/8216
关键词: Nitric oxide synthase 、 Peptide sequence 、 Biophysics 、 PDZ domain 、 Peptide binding 、 Signal transducing adaptor protein 、 Biochemistry 、 Chemistry 、 Plasma protein binding 、 Peptide 、 Protein structure
摘要: The PDZ domain of neuronal nitric oxide synthase (nNOS) functions as a scaffold for organizing the signal transduction complex enzyme. NMR structure composed nNOS and an associated peptide suggests that two-stranded beta-sheet C-terminal to canonical may mediate its interaction with domains postsynaptic density-95 alpha-syntrophin. also provides molecular basis recognition Asp-X-Val-COOH peptides by domain. role extension in binding is investigated. Additionally, studies further show from novel cytosolic protein named CAPON bind same pocket
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