Significance of hemolysis on extracorporeal life support after cardiac surgery in children
作者： Rasheed Gbadegesin , Shuang Zhao , John Charpie , Patrick D. Brophy , William E. Smoyer
DOI: 10.1007/S00467-008-1047-Z
关键词: Cardiac surgery 、 Retrospective cohort study 、 Internal medicine 、 Mortality rate 、 Medicine 、 Renal replacement therapy 、 Surgery 、 Extracorporeal membrane oxygenation 、 Extracorporeal 、 Cardiology 、 Nephrology 、 Heart disease 、 Pediatrics, Perinatology, and Child Health
摘要: Hemolysis is common during extracorporeal life support (ECLS). Elevated levels of circulating plasma free hemoglobin (FHb) has been linked to the development hemoglobinuria nephropathy. Its clinical significance in patients receiving ECLS remains unknown. Medical records 104 children <3 years old who required after repair congenital heart disease were reviewed. Forty-two continuous renal replacement therapy (CRRT) (CRRT group), and 62 did not (no-CRRT group). For all patients, FHb level degree fluid overload at end predicted mortality rate ECLS. Compared with no-CRRT group, CRRT group had a higher ECLS, peak more days In death was associated worse function. conclusion, elevated dysfunction undergoing cardiac surgery. Further studies are needed elucidate cause-effect relationship our findings.
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