Reduced femoral neck bone density in the daughters of women with hip fractures: The role of low peak bone density in the pathogenesis of osteoporosis

摘要: Low bone density in women with hip fractures ("senile" osteoporosis) may be due to excessive loss or low peak density. If is responsible, then no reduction expected their daughters. should also reduced daughters because genetic and family environmental factors influence the variability Bone was measured using dual-photon absorptiometry expressed as a standardized deviation Z score relative 697 controls, adjusting for age, height, weight, menopausal status. In 74 fractures, (mean +/- SEM) -0.52 0.14 (P < 0.001) at femoral neck, -1.04 0.17 shaft, -0.43 0.10 lumbar spine. 41 daughters, -0.40 0.05) -0.41 0.19 0.23 0.13 (NS) We conclude that of are likely increased risk themselves they have neck Femoral not entirely attributable trauma; contribute caused by attainment lower