Facile Synthesis of Innocuous Comb-Shaped Polymethacrylates with PEG Side Chains by Nitroxide-Mediated Radical Polymerization in Hydroalcoholic Solutions

摘要: The nitroxide-mediated copolymerization of poly(ethylene glycol) methyl ether methacrylate (MePEGMA) with a small amount acrylonitrile using an SG1-based alkoxyamine initiator was shown to be very simple and efficient technique synthesize graft copolymers side chains. copolymerizations were carried out in ethanol/water solutions as environmentally friendly media. Following our observation that the rate increased proportion water, polymerization temperature low 71 °C could used for water content 75%, which conferred great flexibility process. so-formed living, high crossover efficiency toward block copolymers. Importantly, following cytotoxicity study over three different cell lines represent important mammalian types, these polymers noncytotoxic even at doses without any other purification step than precipitation. These comb-shaped PEG-based may ideal platform synthesis PEGylating moieties proteins nanoparticles intended biomedical field.