Antinociceptive effect of a novel tosylpyrazole compound in mice.

摘要: Abstract:  Pain is the most common complaint in medical field and identification of compounds that can effectively treat painful states without induction side-effects remains a major challenge biomedical research. The aim present study was to investigate antinociceptive effect novel compound, 3-(4-fluorophenyl)-5-trifluoromethyl-1H-1-tosylpyrazole (compound A) several models pain mice compare with those produced by known trifluoromethyl-containing pyrazole compound celecoxib. Compound A or celecoxib were administrated oral (78–780 µmol/kg), intrathecal (9–22.5 nmol/site) intracerebroventricular routes. Oral administration either compound A abolished mechanical allodynia, but not oedema caused intraplantar injection carrageenan. Similarly, reduced overt nociception, oedema, bradykinin capsaicin. However, (500 µmol/kg, orally) did alter nociception nor prostaglandin E2 or glutamate, whereas only induced former. Moreover, also acetic acid. acetic acid-induced when it injected route. Finally, neither able produce tail-flick test motor performance body temperature. Besides, induce gastric lesion. Thus, seems be an interesting prototype for development analgesic drugs.