Antinociceptive effect of novel pyrazolines in mice.

摘要: The antinociceptive effect of six novel synthetic pyrazolines (3-ethoxymethyl-5-ethoxycarbonyl-1H-pyrazole (Pz 1) and its corresponding 1-substituted methyl 2) phenyl 3) analogues, 3-(1-ethoxyethyl)-5-ethoxycarbonyl-1H-pyrazole 4) 5) 6) analogues) was evaluated by the tail immersion test in adult male albino mice. animals (N = 11-12 each group) received vehicle (5% Tween 80, 10 ml/kg, sc) or 1.5 mmol/kg 1-Pz 6), sc. Fifteen, thirty sixty minutes after drug administration, mice were subjected to test. Thirty administration Pz 2 3 increased withdrawal latency (vehicle 3.4 ± 0.2; 5.2 0.4; 5.9 0.4 s; mean SEM), whereas other did not present activity. Dose-effect curves (0.15 mmol/kg) constructed for bioactive pyrazolines. (1.5 mmol/kg, impaired motor coordination rotarod immobility open-field alter performance spontaneous locomotion, but open field at dose mmol/kg. involvement opioid mechanisms pyrazoline-induced antinociception investigated pretreating with naloxone (2.75 µmol/kg, sc). Naloxone prevented 3- 2-induced antinociception. Moreover, pretreatment 3-induced immobility. We conclude that involves this is case 2.