Synthesis of new oxadiazole, pyrazole and pyrazolin-5-one bearing 2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetohydrazide analogs as potential antibacterial and antifungal agents.
作者： M. Mahesh , G. Bheemaraju , G. Manjunath , P. Venkata Ramana
DOI: 10.1016/J.PHARMA.2015.07.002
关键词:
摘要: Two series of diversely substituted phenyldiazenyl(2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetyl)3,5-dimethyl-1H-pyrazole 11a-g and phenyldiazenyl-1-(2-(4-methyl-2-oxo-4-chromen-7-yloxy)acetyl)-3-methyl-1H-pyrazol-5(4)H-one 12a-j were synthesized. All these compounds characterized by IR, NMR, mass spectra elemental analyses. The evaluated for their in vitro antibacterial activity against some Gram-positive bacteria, Staphylococcus aureus, Bacillus subtilis, Gram-negative Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi screened antifungal A. niger, U. maydis. showed moderate to very good activities.
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