作者: D Ginsberg , D Michael-Michalovitz , D Ginsberg , M Oren
DOI: 10.1128/MCB.11.1.582
关键词: Mutant 、 Cell biology 、 Biology 、 Fibroblast 、 Mutation 、 Cell division 、 Cytoplasm 、 Immunology 、 Cell nucleus 、 Nuclear localization sequence 、 Cell growth
摘要: Abstract A temperature-sensitive mutant of p53, p53Val-135, was found to be able arrest cell proliferation when overexpressed at 32.5 degrees C. While much the protein cytoplasmic in cells proliferating 37.5 C, it became predominantly nuclear Concomitantly, p53Val-135 destabilized, although not extent seen primary fibroblasts.