FDG PET and FDG PET/CT in patients with gastrointestinal stromal tumours

作者: Philipp Malle , Manfred Sorschag , Hans-Jürgen Gallowitsch

DOI: 10.1007/S10354-012-0131-Y

关键词: Fdg pet ctMedicineNuclear medicineImatinib mesylateGastrointestinal stromal tumoursIn patientRadiologyClinical OncologyTreatment responsePositron emission tomographySunitinib

摘要: Gastrointestinal stromal tumours (GISTs) are fairly rare neoplasms, constituting less than 3 % of all gastrointestinal malignancies. The integration molecularly targeted treatment regimes (i.e., tyrosine kinase inhibitors) in clinical oncology has revolutionized the management patients with irresectable GISTs or metastatic disease. Malignant usually display increased glucose metabolism and therefore 18F-fluorodeoxyglucose (FDG) uptake within scope positron emission tomography (PET) scans. Nowadays, dual-modality FDG PET/CT (computed tomography) imaging is considerable value diagnostic work-up acquiring functional anatomic information simultaneously. following article sheds light on impact PET combined initial disease evaluation, detection tumour recurrence early assessment response to agents such as imatinib mesylate sunitinib maleate.

参考文章(32)
Helen E. Remotti, Frank Aldenborg, Jeanne M. Meis-Kindblom, Lars Gunnar Kindblom, Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. American Journal of Pathology. ,vol. 152, pp. 1259- 1269 ,(1998)
T. Sauerbruch, T. Heinicke, H. Palmedo, A. Glasmacher, H.J. Tschampa, E. Wardelmann, Very early detection of response to imatinib mesylate therapy of gastrointestinal stromal tumours using 18fluoro-deoxyglucose-positron emission tomography. Anticancer Research. ,vol. 25, pp. 4591- 4594 ,(2005)
Boudewijn E. C. Plaat, Harry Hollema, Willemina M. Molenaar, Gerben H. Torn Broers, Justin Pijpe, Mirjam F. Mastik, Harald J. Hoekstra, Eva van den Berg, Rik J. Scheper, Winette T. A. van der Graaf, Soft Tissue Leiomyosarcomas and Malignant Gastrointestinal Stromal Tumors: Differences in Clinical Outcome and Expression of Multidrug Resistance Proteins Journal of Clinical Oncology. ,vol. 18, pp. 3211- 3220 ,(2000) , 10.1200/JCO.2000.18.18.3211
Jörg Kanja, Andreas Bockisch, Hilmar Kuehl, Lutz S Freudenberg, Jörg F Debatin, Sebastian Bauer, Gerald Antoch, Katrin Renzing-Koehler, Jochen Schuette, Comparison of PET, CT, and Dual-Modality PET/CT Imaging for Monitoring of Imatinib (STI571) Therapy in Patients with Gastrointestinal Stromal Tumors The Journal of Nuclear Medicine. ,vol. 45, pp. 357- 365 ,(2004)
Donald Podoloff, Isis Gayed, Marcella Johnson, Revathy Iyer, Homer Macapinlac, Nancy Swanston, Thuan Vu, The Role of 18F-FDG PET in Staging and Early Prediction of Response to Therapy of Recurrent Gastrointestinal Stromal Tumors The Journal of Nuclear Medicine. ,vol. 45, pp. 17- 21 ,(2004)
Yoichi Otomi, Hideki Otsuka, Naomi Morita, Kaori Terazawa, Kaori Furutani, Masafumi Harada, Hiromu Nishitani, Relationship between FDG uptake and the pathological risk category in gastrointestinal stromal tumors The Journal of Medical Investigation. ,vol. 57, pp. 270- 274 ,(2010) , 10.2152/JMI.57.270
Ronald P. DeMatteo, Robert G. Maki, Cristina Antonescu, Murray F. Brennan, Targeted molecular therapy for cancer: The application of STI571 to gastrointestinal stromal tumor Current Problems in Surgery. ,vol. 40, pp. 131- 193 ,(2003) , 10.1016/S0011-3840(03)80001-1
Michael C. Heinrich, Brian P. Rubin, B.Jack Longley, Jonathan A. Fletcher, Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations Human Pathology. ,vol. 33, pp. 484- 495 ,(2002) , 10.1053/HUPA.2002.124124
Christopher D.M. Fletcher, Jules J. Berman, Christopher Corless, Fred Gorstein, Jerzy Lasota, B.Jack Longley, Markku Miettinen, Timothy J. O'Leary, Helen Remotti, Brian P. Rubin, Barry Shmookler, Leslie H. Sobin, Sharon W. Weiss, Diagnosis of gastrointestinal stromal tumors: A consensus approach Human Pathology. ,vol. 33, pp. 459- 465 ,(2002) , 10.1053/HUPA.2002.123545
Nadir Ghanem, Carsten Altehoefer, Alex Furtwängler, Jan Winterer, Oliver Schäfer, Oliver Springer, Elmar Kotter, Mathias Langer, Computed tomography in gastrointestinal stromal tumors. European Radiology. ,vol. 13, pp. 1669- 1678 ,(2003) , 10.1007/S00330-002-1803-6