Fiducial Markers for Distribution of Drug and Excipient on Tablet Surfaces by Multimodal Desorption Electrospray Ionization–Mass Spectrometry (DESI–MS) Imaging

摘要: Fiducial markers are necessary for the accurate overlay of images obtained by different methods from small areas a sample. Thus far, fiducial have been used biological sample analysis mass spectrometry imaging. In this work, spatial distributions excipient and active drug substance at surfaces tablets produced under pressures observed multimodal desorption electrospray ionization–mass (DESI-MS) imaging with two novel marker systems being to achieve ion optical images. DESI-MS in negative positive modes as well circa 3 mm2 precisely superimposed, allowing observing particulate composition tablet's ingredients, feature that is remarkably conserved spite pressure produce tablet. This approach can be applied broadly product development, quality control, counterfeit detection. [Supplementary...