Developmental perspectives in pediatric psychopharmacology.

摘要: Compared with adults, children and adolescents respond to psychotropic medications in some distinctive ways that have implications for both efficacy safety. Age-related differences pharmacokinetics pharmacodynamics account of these differences. But while the disposition several psychotropics has been studied, pharmacodynamic effects interaction between drug developing brain are still largely unknown. There is now evidence major neurotransmitter systems undergo developmental changes can extend into second decade life. Data from various animal models also show administration pre-and perinatal period interfere development produce permanent system question. The extrapolation data humans difficult. Given increase use pediatric age, need emerges systematic investigation on long-term drugs brain.