Recent advances in neuroimaging of multiple sclerosis.

摘要: Conventional magnetic resonance imaging (MRI) is sensitive in detecting abnormalities multiple sclerosis (MS), but these tend not to be pathologically specific. The visible T2 lesions are diagnostically valuable and may allow earlier diagnosis of the disease more accurate prognostication. Quantitative MR techniques such as volume measurement can reveal pathology nonlesional tissue with some clinical correlation; however, pathological interpretation at a cellular level problematic given current resolution MRI. In this update, recent studies using conventional quantitative discussed new, promising non-MRI methodologies highlighted, including retinal nerve fiber layer estimation. role MRI measuring metabolic function, functional measures investigating nonlocomotor symptoms cognition, also future improvements currently employed research studies. With increased sophistication improved analysis techniques, understanding underlying MS increase, objective quantification natural history possible.