Multiannual patterns of influenza A transmission in Chinese live bird market systems

摘要: Please cite this paper as: Pepin et al. (2012) Multiannual patterns of influenza A transmission in Chinese live bird market systems. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750-2659.2012.00354.x. Background  Avian viruses (AIV) cause huge economic losses poultry industries pose a substantial threat to human health. However, predicting AIV epizootics emergence humans is confounded by insufficient empirical data on the ecology dynamics To address gap, we quantified incidence for 13 hemagglutinin subtypes using 6 years surveillance that were collected from ten different species three types holdings (contexts) – retail, wholesale, or farms. Methods  We 42 646 samples Shantou, China between 2000 2006. screened 1–13 Paramyxovirus-type-1 (APMV-1) monospecific antisera hemagglutination inhibition tests. analyzed determine seasonality patterns, subtype–host, subtype–subtype interactions as well subtype bias contexts. Results  H3, H6, H9, APMV-1 most prevalent. No significant was found when all considered together. For APMV-1, there specificity host, context, coinfection partner. H5 showed generalized host usage pattern, followed H9 H6. Conclusion  Subtype-specific because other suggest risk assessments exclude these details are likely inaccurate. Surveillance should include longitudinal sampling multiple contexts. Quantitative models control strategies must consider subtypes, hosts, source contexts assess effectiveness interventions.