MaveDB: an open-source platform to distribute and interpret data from multiplexed assays of variant effect

摘要: Multiplex assays of variant effect (MAVEs), such as deep mutational scans and massively parallel reporter assays, test thousands sequence variants in a single experiment. Despite the importance MAVE data for basic clinical research, there is no standard resource their discovery distribution. Here, we present MaveDB ( https://www.mavedb.org ), public repository large-scale measurements impact, designed interoperability with applications to interpret these datasets. We also describe first application, MaveVis, which retrieves, visualizes, contextualizes maps. Together, database will empower community mine powerful