Amidation of saturated C-H bonds catalyzed by electron-deficient ruthenium and manganese porphyrins. A highly catalytic nitrogen atom transfer process.
作者： Xiao-Qi Yu , Jie-Sheng Huang , Xiang-Ge Zhou , Chi-Ming Che
DOI: 10.1021/OL000107R
关键词: Substrate (chemistry) 、 Amination 、 Medicinal chemistry 、 Ruthenium 、 Reagent 、 Organic chemistry 、 Yield (chemistry) 、 Manganese 、 Catalysis 、 Chemistry 、 Electron
摘要: Amidation of a variety hydrocarbons with PhI=NTs catalyzed by ruthenium and manganese meso-tetrakis(pentafluorophenyl)porphyrins 1 2 afforded N-substituted amides in up to 92% yields good excellent substrate conversions. By employing catalyst 2, exceptionally high turnovers (up 2600) were achieved, the amidations can be effected directly using PhI(OAc)(2)/NH(2)R as amidating reagents; case R = COCF(3) direct amination was realized 90% yield.
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