Novel assay for inhibitors of egfr

作者: Xuewu Zhang , Natalia Jura , John Kuriyan

DOI:

关键词: Molecular biologyKinaseComputational biologyChemistry

摘要: The invention provides methods and compositions for screening modulators of EGFR activity. In particular, an assay such is provided, which includes using models the three dimensional structure kinase domains.

参考文章(12)
Zakaria Rachid, Bertrand Jean-Claude, Fouad Brahimi, Novel combi-molecules having EGFR and DNA targeting properties ,(2005)
Matthias H. Kraus, C. Richter King, Stuart A. Aaronson, erbB-2 gene segments, probes, recombinant DNA and kits for detection ,(1995)
Lewis C. Cantley, Zhou Songyang, Substrate specificity of protein kinases ,(1995)
L. Michael Furness, Jenny L. Buchbinder, Genes expressed in C3A liver cell cultures treated with steroids ,(2001)
Liao Jeffrey, Andrews Robert, Targeting protein multiple conformations: a structure-based strategy for kinase drug design. Current Topics in Medicinal Chemistry. ,vol. 7, pp. 1394- 1407 ,(2007) , 10.2174/156802607781696783
Ming-Hui Wei, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley, Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof ,(2001)
Xuewu Zhang, Jodi Gureasko, Kui Shen, Philip A. Cole, John Kuriyan, An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor Cell. ,vol. 125, pp. 1137- 1149 ,(2006) , 10.1016/J.CELL.2006.05.013
Martin EM Noble, Jane A Endicott, Louise N Johnson, Protein Kinase Inhibitors: Insights into Drug Design from Structure Science. ,vol. 303, pp. 1800- 1805 ,(2004) , 10.1126/SCIENCE.1095920
Ram Thaimattam, Rahul Banerjee, Rajni Miglani, Javed Iqbal, None, Protein Kinase Inhibitors: Structural Insights Into Selectivity Current Pharmaceutical Design. ,vol. 13, pp. 2751- 2765 ,(2007) , 10.2174/138161207781757042