Alterations of negative regulators of cytokine signalling in immunodeficiency-related non-Hodgkin lymphoma.

摘要: We investigated immunodeficiency-related non-Hodgkin lymphoma for the presence of molecular alterations affecting negative regulators Janus family protein tyrosine kinase/signal transducer and activator transcription pathway. Protein phosphatase, non-receptor type 6/Src homology 2-containing phosphatase-1 epigenetic silencing was recurrent in primary effusion (100%), diffuse large B-cell (63%), with a higher prevalence non-germinal centre subtype, associated activation 3 Suppressor cytokine signalling (SOCS)1 SOCS3 were occasionally detected, whereas SOCS1 frequently mutated polymorphic post-transplant lymphoproliferative disorders, possibly as cause aberrant somatic hypermutation. However, mutation profile coding region gene different from that expected hypermutation process, suggesting that, at least some cases, mutations may have been selected their functional activity.