摘要: … , is enhanced in SHP1 −/− macrophages 44 . Genetic studies indicate that SHP2 is … interaction is cytokine dependent and PIAS proteins do not interact with STATs in unstimulated cells…
Ben A Croker, Danielle L Krebs, Jian-Guo Zhang, Sam Wormald, Tracy A Willson, Edouard G Stanley, Lorraine Robb, Christopher J Greenhalgh, Irmgard Förster, Björn E Clausen, Nicos A Nicola, Donald Metcalf, Douglas J Hilton, Andrew W Roberts, Warren S Alexander, SOCS3 negatively regulates IL-6 signaling in vivo.Nature Immunology. ,vol. 4, pp. 540- 545 ,(2003) , 10.1038/NI931