Role of p63 and basal cells in the prostate

摘要: The prostate contains two major epithelial cell types – luminal and basal cells - both of which develop from urogenital sinus epithelium. linage relationship between these is not clear. Here we demonstrate that can independently cells, but are essential for maintaining ductal integrity the proper differentiation cells. Urogenital (UGS) isolated p63 +/+ –/– embryos developed into when grafted adult male nude mice. Prostatic tissue in UGS grafts contained neuroendocrine were absent. Therefore, thus required prostatic also atypical mucinous appeared to differentiate via activation Src. In response castration, regression was inordinately severe with almost complete loss ducts, resulting formation residual cystic structures devoid play critical roles survival However, regressed did regenerate androgen administration, indicating regeneration.