Metabolic alterations associated with polycystic ovary syndrome: A UPLC Q-Exactive based metabolomic study.
作者： Xiaojiao Chen , Ting Lu , Xiaoxiao Wang , Xian Sun , Junqiang Zhang
DOI: 10.1016/J.CCA.2019.11.016
关键词: Biomarker (medicine) 、 KEGG 、 Metabolic pathway 、 Follicular fluid 、 Endocrinology 、 Metabolomics 、 Polycystic ovary 、 Endocrine system 、 Medicine 、 Internal medicine 、 Metabolic disorder
摘要: Abstract Background The polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder of women in reproductive age. Metabolomic studies follicular fluid can reveal potential pathways related to PCOS. objection this study was explore changes metabolites Methods We collected samples 35 patients with PCOS 33 controls without for metabolomic analysis UPLC Q-Exactive. identified were annotated KEGG HMDB determine disturbances Based on regression model, we conducted ROC find biomarker fluid. Results 21 differential PCOS, which revealed that Vitamin B6 metabolism, phenylalanine metabolism carnitine synthesis key changed pathways. found 7β-Hydroxycholesterol based analysis. Conclusion alterations providing novel ways diagnosis treatment
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