Intra-tumoral injection of CpG results in the inhibition of tumor growth in murine Colon-26 and B-16 tumors.
作者： Sanjay Sharma , Constantine P. Karakousis , Hiroshi Takita , Kyu Shin , Stephen P. Brooks
关键词: Cancer 、 Lethal dose 、 Therapeutic effect 、 Tumor growth 、 Medicine 、 Cancer research 、 Melanoma 、 CpG Oligodeoxynucleotide 、 CpG site 、 CD8 、 Immunology
摘要: Direct tumor injections of CpG (ODN #1826) into murine tumors markedly suppressed the growth and increased survival mice. Tumor was reduced by 60–67% in Colon 26 (CT-26) B-16 melanoma treated with as compared to untreated one. In CT-26 CpG, average animals were prolonged 28 d 16 18 control respectively. Long-term surviving groups also protected from a subsequent injection lethal dose cells. present study, effect mediated through CD8+ T cells, their depletion resulted abrogation therapeutic effects CpG. It suggests that direct might be simple means achieving clinical response cancer patients.
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sci-hub.se 参考文章(14)
Hsin-Ming Liu, Sally E. Newbrough, Sudershan K. Bhatia, Christopher E. Dahle, Arthur M. Krieg, George J. Weiner, Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocyte-macrophage colony-stimulating factor. Blood. ,vol. 92, pp. 3730- 3736 ,(1998) , 10.1182/BLOOD.V92.10.3730
You Kawarada, Ruth Ganss, Natalio Garbi, Torsten Sacher, Bernd Arnold, Günter J. Hämmerling, NK- and CD8(+) T cell-mediated eradication of established tumors by peritumoral injection of CpG-containing oligodeoxynucleotides. Journal of Immunology. ,vol. 167, pp. 5247- 5253 ,(2001) , 10.4049/JIMMUNOL.167.9.5247
Jean-Yves Delattre, Lin Chen, Fabrice Maltonti, Antoine F. Carpentier, Oligodeoxynucleotides containing CpG motifs can induce rejection of a neuroblastoma in mice. Cancer Research. ,vol. 59, pp. 5429- 5432 ,(1999)
Edith Mathiowitz, Richard B. Bankert, Yong S. Jong, Nejat K. Egilmez, Michael S. Sabel, Jules S. Jacob, In situ tumor vaccination with interleukin-12-encapsulated biodegradable microspheres: induction of tumor regression and potent antitumor immunity. Cancer Research. ,vol. 60, pp. 3832- 3837 ,(2000)
Risini D Weeratna, Michael J McCluskie, Yu Xu, Heather L Davis, CpG DNA induces stronger immune responses with less toxicity than other adjuvants. Vaccine. ,vol. 18, pp. 1755- 1762 ,(2000) , 10.1016/S0264-410X(99)00526-5
G. Hartmann, G. J. Weiner, A. M. Krieg, CpG DNA : a potent signal for growth, activation, and maturation of human dendritic cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 9305- 9310 ,(1999) , 10.1073/PNAS.96.16.9305
Eduardo Davila, Esteban Celis, Repeated Administration of Cytosine-Phosphorothiolated Guanine-Containing Oligonucleotides Together with Peptide/Protein Immunization Results in Enhanced CTL Responses with Anti-Tumor Activity Journal of Immunology. ,vol. 165, pp. 539- 547 ,(2000) , 10.4049/JIMMUNOL.165.1.539
George J. Weiner, The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides. Journal of Leukocyte Biology. ,vol. 68, pp. 455- 463 ,(2000) , 10.1189/JLB.68.4.455
Sanjay Gurunathan, Dennis M. Klinman, Robert A. Seder, DNA Vaccines: Immunology, Application, and Optimization Annual Review of Immunology. ,vol. 18, pp. 927- 974 ,(2000) , 10.1146/ANNUREV.IMMUNOL.18.1.927
Michael J. McCluskie, Risini D. Weeratna, Heather L. Davis, The role of CpG in DNA vaccines. Springer Seminars in Immunopathology. ,vol. 22, pp. 125- 132 ,(2000) , 10.1007/S002810000014