Neutrophil CD64 combined with PCT, CRP and WBC improves the sensitivity for the early diagnosis of neonatal sepsis.

摘要: BACKGROUND The aim of this study was to determine whether neutrophil CD64 (nCD64) combined with procalcitonin (PCT), C-reactive protein (CRP) and white blood cell count (WBC) can increase the sensitivity accuracy neonatal sepsis diagnosis. METHODS serum levels nCD64, CRP, PCT WBC were detected in 60 patients non-sepsis. Sensitivity, specificity, positive negative predictive values, receiver operating characteristic (ROC) area under curve (AUC), logistic regression analysis performed evaluate diagnostic value these markers on sepsis. RESULTS Serum PCT, CRP higher group than non-sepsis (p<0.001). sensitivities at recommended cut-off level for all infants 79.5%, 68.2%, 38.6% 52.3%, respectively. best combination nCD64 which obtained 90.9%, largest AUC 0.922, a 89.2%. However by using an optimal value, four biomarkers diagnosis increased 95.5%. Except WBC, birth weight gestational age had no effects biomarkers. CONCLUSIONS are better early as compared CRP. With help based ROC analysis, could improve suspected late-onset common